Some creatures (and some character birthsigns) have natural weaknesses to magic.
Magnitudes greater than 100% are possible if multiple effects are simultaneously active. Therefore, Weakness to Magic 50% followed by Weakness to Fire 50% results in a 75% magnitude Weakness to Fire effect. All of the effects listed as offensive spells will be enhanced by an active Weakness to Magic effect, including subsequent Weakness spells. For example, a target with Weakness to Magic 50% active will suffer 9 points of damage from a Flare spell, instead of the usual 6 points. Weakness to Magic increases by M% the magnitude of subsequent offensive magical effects the effect lasts for D seconds.